INT339732

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.45
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (TRO) plasma membrane (TRO) nucleus (TRO)
cytoplasm (TRO)
Anatomy Link Frequency
liver 1
hepatocytes 1
TRO (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 99 99.76 Very High Very High Very High
Inflammatory mediators 3 10.08 Low Low
cytokine 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Bile 6 5.00 Very Low Very Low Very Low
COX2 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteogenic Sarcomas 3 96.80 Very High Very High Very High
Death 9 93.84 High High
Stress 12 90.20 High High
Apoptosis 24 80.56 Quite High
Insulin Resistance 18 56.04 Quite High
Obesity 129 28.40 Quite Low
Diabetes Mellitus 66 22.52 Low Low
INFLAMMATION 12 9.68 Low Low
Toxicity 30 5.00 Very Low Very Low Very Low
Hepatotoxicity 27 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
agonists, including TRO, CIG, ROSI, and PIO, in rat hepatocytes after a 6-hour treatment.
Regulation (after) of TRO in hepatocytes associated with agonist
1) Confidence 0.14 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.49 Pain Relevance 0.05
A TRO response closer to CIG than to the second TZDs generation, ROSI and PIO, was also found in the C9 rat liver cell line [36].
Regulation (response) of TRO in liver
2) Confidence 0.09 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.46 Pain Relevance 0.04
Around 2-fold more genes were modulated in TRO- and CIG- than in ROSI- and PIO-treated cell samples.
Regulation (modulated) of TRO
3) Confidence 0.09 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.50 Pain Relevance 0.05

General Comments

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