INT339746

Context Info Confidence 0.21 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.35 Pain Relevance 0

mitochondrion (PCK2) small molecule metabolic process (PCK2) lyase activity (PCK2) carbohydrate metabolic process (PCK2)

Anatomy Link Frequency liver 1 PCK2 (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 33 50.00 cytokine 2 5.00 Inflammatory response 2 5.00 Bile 2 5.00 COX2 1 5.00 Inflammation 1 5.00 Paracetamol 1 5.00 Inflammatory mediators 1 5.00

Disease Link Frequency Relevance Heat Fatty Liver 3 78.40 Obesity 43 75.28 Body Weight 1 71.56 Diabetes Mellitus 22 56.24 Toxicity 10 5.00 Hepatotoxicity 9 5.00 Hepatocellular Cancer 8 5.00 Apoptosis 8 5.00 Insulin Resistance 6 5.00 Stress 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

, sterol regulatory element binding protein 1 (Srebp1), phosphoenolpyruvate carboxykinase (Pepck), and glucose transporter type 2 (Glut-2 or Slc2a2) expression levels, leading to the conclusion that there is an adipogenic conversion of the liver when PPAR?

Phosphorylation (phosphoenolpyruvate carboxykinase) of Pepck in liver

1) Confidence 0.21 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.35 Pain Relevance 0

General Comments

This test has worked.