INT339817

Context Info Confidence 0.12 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.08 Pain Relevance 0

response to stress (UCN2) cytoplasm (SRP72) cell proliferation (UCN2) cytosol (SRP72) extracellular space (UCN2) extracellular region (UCN2)

Anatomy Link Frequency nucleus 1 SRP72 (Homo sapiens) UCN2 (Homo sapiens)

Pain Link Frequency Relevance Heat Sicca syndrome 2 33.00 tolerance 7 28.04 Osteoarthritis 2 11.08 rheumatoid arthritis 3 10.32 Inflammation 6 5.00 cytokine 2 5.00 Inflammatory mediators 1 5.00 IPN 1 5.00 Arthritis 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 8 78.08 Syndrome 2 33.00 Systemic Lupus Erythematosus 2 32.16 Dermatomyositis 9 22.20 Polymyositis 1 21.92 Disease 1 16.68 Osteoarthritis 2 11.08 Rheumatoid Arthritis 3 10.32 Rheumatic Diseases 5 9.28 INFLAMMATION 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

in Jurkat cells tested with MAPK inhibitors, showing no effect on mRNA expression of the SRP72 gene, which could explain that the SRP72 and all the components of the SRP complex are synthesized and assembled inside the nucleus to do their functions in the cytoplasm (2, 35).

SRP72 Binding (complex) of SRP in nucleus

1) Confidence 0.12 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0.08 Pain Relevance 0

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