INT339991

Context Info Confidence 0.34 First Reported 2011 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.30 Pain Relevance 0.06

cell differentiation (SIRT1) nucleoplasm (SIRT1) mitochondrion (SIRT1) nuclear envelope (SIRT1) histone binding (SIRT1) enzyme binding (SIRT1)

Anatomy Link Frequency nucleus 1 SIRT1 (Homo sapiens)

Pain Link Frequency Relevance Heat Potency 2 62.56 Chronic pancreatitis 6 5.00 cytokine 2 5.00 chemokine 2 5.00 Inflammation 2 5.00

Disease Link Frequency Relevance Heat Fungal Infection 2 80.24 Thyroid Neoplasm 4 72.96 Cancer 90 50.00 Disease 8 50.00 Metastasis 8 8.76 Pancreatic Cancer 48 6.92 Apoptosis 38 5.00 Death 28 5.00 Adenocarcinoma 20 5.00 Lymphatic System Cancer 12 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Whereas three SIRT proteins (SIRT1, SIRT6, and SIRT7) are nuclear localized, SIRT3, SIRT4, and SIRT5 are localized in the mitochondria and SIRT2 is a cytoplasmic protein [8].

Localization (localized) of SIRT1

1) Confidence 0.34 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 0.15 Pain Relevance 0.03

While Class II HDACs are able to shuttle in and out of the nucleus, the Class III sirtuin family (SIRT1-7) has a different localization.

Localization (localization) of SIRT1-7 in nucleus

2) Confidence 0.34 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 0.15 Pain Relevance 0.03

General Comments

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