INT340536

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.39
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Myog) nucleus (Myog) DNA binding (Myog)
Anatomy Link Frequency
muscle 2
gastrocnemius 1
Myog (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 36 77.92 Quite High
agonist 4 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 80 98.90 Very High Very High Very High
Cancer 172 92.84 High High
Injury 8 89.68 High High
Body Weight 24 87.56 High High
Appetite Loss 84 84.12 Quite High
Colon Cancer 4 84.08 Quite High
Muscular Atrophy 52 77.52 Quite High
Aging 16 71.52 Quite High
Chronic Renal Failure 4 71.40 Quite High
Syndrome 8 68.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study demonstrates that in the muscle of the C26 hosts Pax7 expression is significantly increased with respect to controls, while myogenin levels are reduced.
Negative_regulation (reduced) of myogenin in muscle
1) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.74 Pain Relevance 0
MyoD levels, previously reported to be reduced in the muscle of AH-130 bearers [20], are unaffected in the gastrocnemius of the C26 hosts (Fig. 5B), while the marked decrease of myogenin is rescued by PD treatment (Fig. 5B).
Negative_regulation (decrease) of myogenin in gastrocnemius
2) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.58 Pain Relevance 0
During differentiation, phosphorylated ERK, occurring at high levels over days 1–3, progressively declines concomitantly with Pax7 reduction and myogenin and MyoD increases (Fig.
Negative_regulation (reduction) of myogenin
3) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.27 Pain Relevance 0
In C26 hosts, muscle wasting is also associated with increased Pax7 expression and reduced myogenin levels.
Negative_regulation (reduced) of myogenin in muscle associated with frailty
4) Confidence 0.18 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2965098 Disease Relevance 0.79 Pain Relevance 0.04

General Comments

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