INT340553

Context Info Confidence 0.04 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.52 Pain Relevance 0.07

nucleus (Pik3r1, Fbxo32) intracellular (Pik3r1) protein complex (Pik3r1) cytoplasm (Pik3r1) cytosol (Pik3r1) signal transduction (Pik3r1)

Pik3r1 (Mus musculus) Fbxo32 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 9 83.52 agonist 1 5.00 tolerance 1 5.00 anesthesia 1 5.00 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Cancer 43 91.04 Frailty 20 81.84 Appetite Loss 21 64.16 Muscular Atrophy 13 52.84 Apoptosis 1 19.12 Body Weight 6 5.00 Aging 4 5.00 Carcinoma 4 5.00 Hypertrophy 3 5.00 Hepatocellular Cancer 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This finding is of particular interest in that confirming that atrogin-1 expression and protein breakdown are not regulated by the PI3K/Akt pathway only [6].

PI3K Regulation (regulated) of Gene_expression (expression) of atrogin-1

1) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.52 Pain Relevance 0.07

General Comments

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