INT340897

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Context Info
Confidence 0.34
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.86
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hspb2) response to stress (Hspb2) cytoplasm (Hspb2)
Anatomy Link Frequency
muscle 1
brain 1
Hspb2 (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 16 98.84 Very High Very High Very High
Hippocampus 8 98.28 Very High Very High Very High
Spinal cord 2 81.16 Quite High
cerebral cortex 4 79.56 Quite High
medulla 8 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Thalamus 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Hsan 2 5.00 Very Low Very Low Very Low
dopamine receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 1 99.84 Very High Very High Very High
Stress 28 98.72 Very High Very High Very High
Muscle Disease 4 98.22 Very High Very High Very High
Shock 31 95.76 Very High Very High Very High
Apoptosis 29 92.40 High High
Death 6 91.72 High High
Motor Neuron Diseases 2 83.28 Quite High
Aging 2 82.84 Quite High
Heat Stress Disorders 1 73.92 Quite High
Disease 22 71.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whether the myopathy is due to the absence of Hspb5 is uncertain because the targeted deletion of Hspb5 also inactivates an overlapping gene, Hspb2 that is highly expressed in muscle.
Positive_regulation (inactivates) of Hspb2 in muscle associated with muscle disease
1) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.63 Pain Relevance 0
They also showed that Hspb2 is inducible, however, to detectable levels in brain.
Positive_regulation (inducible) of Hspb2 in brain
2) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.09 Pain Relevance 0.26
Curcumin increased total HSP27 in glioma cells cultured under stress-conditions by prolonging the stress-induced activation of the heat shock element-binding activity of heat shock transcription factor [82].
Positive_regulation (increased) of HSP27 associated with stress, shock and glioma
3) Confidence 0.22 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 1.15 Pain Relevance 0

General Comments

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