INT340924

Context Info Confidence 0.00 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

cytoplasm (PIK3CB, AKT1) cytosol (PIK3CB, AKT1) signal transduction (PIK3CB, AKT1) nucleus (PIK3CB, AKT1) cell differentiation (AKT1) nucleoplasm (AKT1)

PIK3CB (Homo sapiens) AKT1 (Homo sapiens)

Pain Link Frequency Relevance Heat cerebral cortex 5 5.00 Somatosensory cortex 4 5.00 gABA 3 5.00 anesthesia 1 5.00 alcohol 1 5.00 interneuron 1 5.00 Hippocampus 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Disseminated Intravascular Coagulation 10 5.00 Malformations Of Cortical Development 7 5.00 Neurodegenerative Disease 6 5.00 Epilepsy 1 5.00 Syndrome 1 5.00 Schizophrenia 1 5.00 Intellectual Impairment 1 5.00 Injury 1 5.00 Autism 1 5.00 Disorder Of Lipid Metabolism 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To further assess the influence of intracellular reelin signaling, we used PP2 (10 µM), a Src inhibitor, which blocks Dab1 phosphorylation, as well as LY294002, which by inhibiting PI3K prevents the activation of Akt.

PI3K Negative_regulation (prevents) of Positive_regulation (activation) of Akt

1) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0

General Comments

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