INT341019

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 0.10 Pain Relevance 0.05

extracellular space (VLDLR, Reln) transport (VLDLR) cytoplasm (Reln) peptidase activity (Reln) signal transduction (VLDLR) extracellular region (Reln)

Anatomy Link Frequency neuronal 2 VLDLR (Homo sapiens) Reln (Mus musculus)

Pain Link Frequency Relevance Heat Hippocampus 4 99.72 gABA 12 39.36 cerebral cortex 20 28.28 Somatosensory cortex 16 5.00 anesthesia 4 5.00 alcohol 4 5.00 interneuron 4 5.00 imagery 4 5.00

Disease Link Frequency Relevance Heat Disorder Of Lipid Metabolism 4 99.60 Malformations Of Cortical Development 28 46.08 Neurodegenerative Disease 24 14.60 Disseminated Intravascular Coagulation 40 5.00 Epilepsy 4 5.00 Syndrome 4 5.00 Schizophrenia 4 5.00 Intellectual Impairment 4 5.00 Injury 4 5.00 Autism 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Reelin signaling requires binding to receptors of the lipoprotein family, very low density-lipoprotein (VLDLR) and the apolipoprotein E receptor (ApoER2), which triggers tyrosine phosphorylation of the cytoplasmic adapter protein Disabled-1 (Dab1) [34], [35], [36].

VLDLR Binding (binding) of Reelin associated with disorder of lipid metabolism

1) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.10 Pain Relevance 0.05

Jossin et al. [56] demonstrate that the central fragment of reelin binds to ApoER2 and VLDLR but does not bind to cadherin-related neuronal receptors.

VLDLR Neg (not) Binding (bind) of reelin in neuronal

2) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0

Jossin et al. [56] demonstrate that the central fragment of reelin binds to ApoER2 and VLDLR but does not bind to cadherin-related neuronal receptors.

VLDLR Binding (binds) of reelin in neuronal

3) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0

RAP (300 nM) (human recombinant Receptor Associated Protein), prevents the binding of reelin to both ApoE2R and VLDLR [46], [47].

VLDLR Binding (binding) of reelin

4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0

General Comments

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