INT341023

Context Info Confidence 0.03 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.06 Pain Relevance 0

cytoplasm (PIK3CB, Nrg1) cell morphogenesis (Nrg1) cell proliferation (Nrg1) cytosol (PIK3CB) signal transduction (PIK3CB) extracellular space (Nrg1)

PIK3CB (Homo sapiens) Nrg1 (Mus musculus)

Pain Link Frequency Relevance Heat cerebral cortex 5 5.00 Somatosensory cortex 4 5.00 gABA 3 5.00 anesthesia 1 5.00 alcohol 1 5.00 interneuron 1 5.00 Hippocampus 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Malformations Of Cortical Development 7 60.64 Disseminated Intravascular Coagulation 10 5.00 Neurodegenerative Disease 6 5.00 Epilepsy 1 5.00 Syndrome 1 5.00 Schizophrenia 1 5.00 Intellectual Impairment 1 5.00 Injury 1 5.00 Autism 1 5.00 Disorder Of Lipid Metabolism 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We further investigated the effects induced by reelin and found that signaling was mediated via VLDLR/Dab1/Pi3K activation while NRG1 signaling was mediated via erbB3/erbB4/Pi3K.

Pi3K Positive_regulation (mediated) of NRG1

1) Confidence 0.03 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2965671 Disease Relevance 0.06 Pain Relevance 0

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