INT341218

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 16
Disease Relevance 2.65
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Eif4e, Eif4ebp1) cytoplasm (Eif4e, Eif4ebp1) RNA binding (Eif4e)
nucleus (Eif4ebp1) translation (Eif4e)
Eif4e (Mus musculus)
Eif4ebp1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 576 99.12 Very High Very High Very High
cerebral cortex 160 96.44 Very High Very High Very High
alcohol 16 67.72 Quite High
anesthesia 16 37.12 Quite Low
addiction 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 560 99.12 Very High Very High Very High
Stress 448 99.04 Very High Very High Very High
Cv General 4 Under Development 16 70.40 Quite High
Glioma 16 69.16 Quite High
Alzheimer's Dementia 16 68.84 Quite High
Toxicity 16 68.08 Quite High
Brain Disease 16 66.68 Quite High
Body Weight 16 29.64 Quite Low
Hypoxia 96 22.24 Low Low
Cancer 96 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Table 1 shows the phosphorylation-dependent 4E-BP1 interaction with eIF4E according to the conventional and the new model.
eIF4E Binding (interaction) of 4E-BP1
1) Confidence 0.19 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.09 Pain Relevance 0
On the contrary, in the established model, these signaling pathways would retain 4E-BP1 associated with eIF4E, thus inhibiting eIF4E.
eIF4E Binding (associated) of 4E-BP1
2) Confidence 0.19 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.14 Pain Relevance 0.03
Moreover, in this new model, in the event of the phosphorylation on Thr69, 4E-BP1 would remain associated with eIF4E, whereas in the conventional model, this might not occur.
eIF4E Spec (might) Binding (associated) of 4E-BP1
3) Confidence 0.19 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.14 Pain Relevance 0.04
Our results demonstrate that Thr69 phosphorylation alone allows binding to eIF4E, and subsequent Thr36/Thr45 phosphorylation is sufficient to dissociate 4E-BP1 from eIF4E.
eIF4E Binding (dissociate) of 4E-BP1
4) Confidence 0.15 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.14 Pain Relevance 0
Association of eIF4E with eIF4G and 4E-BP1
eIF4E Binding (Association) of 4E-BP1
5) Confidence 0.15 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0 Pain Relevance 0.06
The individual contribution of the 4E-BP1 phosphorylation sites to the control of eIF4E binding remains controversial. 4E-BP1 phosphorylated on Th36/Thr45 retains the ability to interact with eIF4E (10).
eIF4E Binding (interact) of 4E-BP1
6) Confidence 0.15 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.51 Pain Relevance 0.07
To study eIF4F complex formation and 4E-BP1 and eIF4G association with eIF4E, a cap-containing matrix was used as described previously (16, 19).
eIF4E Binding (association) of 4E-BP1
7) Confidence 0.15 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0 Pain Relevance 0.06
R30 induced a significant decrease in 4E-BP1 bound to eIF4E when compared with the SHC control or I15 condition, and accordingly, induced a significant increase in eIF4G/eIF4E association (Fig. 4; supplemental Fig.
eIF4E Binding (bound) of 4E-BP1 associated with ischemia
8) Confidence 0.14 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.18 Pain Relevance 0.13
However, Ser64 phosphorylation might be dispensable for dissociation from eIF4E (29), and it has suggested that phosphorylation at this site prevents the reassociation of eIF4E and 4E-BP1 (37).
eIF4E Binding (reassociation) of 4E-BP1
9) Confidence 0.14 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.18 Pain Relevance 0
No 4E-BP1 phosphorylated at Thr69/Thr36/Thr45 nor Thr69/Thr36/Thr45/Ser64 was associated with eIF4E.


eIF4E Binding (associated) of 4E-BP1
10) Confidence 0.14 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.31 Pain Relevance 0.13
We studied the phosphorylation of Thr36/Thr45, Ser64, and Thr69 in the 4E-BP1 that was bound to eIF4E.
eIF4E Binding (bound) of 4E-BP1
11) Confidence 0.14 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.17 Pain Relevance 0.17
We studied the phosphorylation status of 4E-BP1 associated with eIF4E and the binding of eIF4G to eIF4E as eIF4F complex formation. eIF4E is identified by its ability to bind to the 5?
eIF4E Binding (associated) of 4E-BP1
12) Confidence 0.14 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.18 Pain Relevance 0.09
Phosphorylation of Thr36/Thr45 does not regulate the binding of 4E-BP1 to eIF4E directly (6), whereas phosphorylation at Ser64 and Thr69 is insufficient to prevent binding to eIF4E (10).
eIF4E Binding (binding) of 4E-BP1
13) Confidence 0.14 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0 Pain Relevance 0
Two-dimensional gel electrophoresis and Western blotting of 4E-BP1 bound to eIF4E detected the ?
eIF4E Binding (bound) of 4E-BP1
14) Confidence 0.14 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.14 Pain Relevance 0.16
form of 4E-BP1 were specific forms bound to eIF4E.
eIF4E Binding (bound) of 4E-BP1
15) Confidence 0.14 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.29 Pain Relevance 0.12
form of 4E-BP1 associated with eIF4E was marked.
eIF4E Binding (associated) of 4E-BP1
16) Confidence 0.14 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.19 Pain Relevance 0.17

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