INT341238

Context Info Confidence 0.03 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.23 Pain Relevance 0.12

translation (EIF4E, Eif4g3) cytosol (EIF4E) RNA binding (Eif4g3) cellular_component (Eif4g3) cytoplasm (EIF4E)

EIF4E (Homo sapiens) Eif4g3 (Mus musculus)

Pain Link Frequency Relevance Heat ischemia 108 67.20 cerebral cortex 30 26.96 addiction 3 5.00 anesthesia 3 5.00 alcohol 3 5.00

Disease Link Frequency Relevance Heat Cv Unclassified Under Development 105 67.20 Stress 84 50.00 Hypoxia 18 5.00 Cancer 18 5.00 Toxicity 3 5.00 Repression 3 5.00 Body Weight 3 5.00 Cv General 4 Under Development 3 5.00 Brain Disease 3 5.00 Alzheimer's Dementia 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This allows eIF4E to bind eIF4G and formation of the eIF4F complex, which leads to translation activation (1–8).

eIF4F Binding (complex) of eIF4G

1) Confidence 0.03 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0 Pain Relevance 0

The assembly of the eIF4F complex is usually defined operationally as the association of eIF4G to eIF4E.

eIF4F Binding (association) of eIF4G

2) Confidence 0.03 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.23 Pain Relevance 0.12

This allows eIF4E to bind eIF4G and formation of the eIF4F complex, which leads to translation activation (1–8).

eIF4F Binding (complex) of eIF4G

3) Confidence 0.03 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0 Pain Relevance 0

General Comments

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