INT341291

Context Info Confidence 0.09 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.34 Pain Relevance 0.45

signal transduction (Tnfrsf11b) extracellular space (Tnfrsf11b) extracellular region (Tnfrsf11b) proteinaceous extracellular matrix (Tnfrsf11b) extracellular matrix organization (Tnfrsf11b)

Anatomy Link Frequency osteoblast 2 Tnfrsf11b (Rattus norvegicus)

Pain Link Frequency Relevance Heat Cancer pain 22 83.84 nociceptor 3 83.84 Pain 52 77.64 Intractable pain 2 57.92 imagery 30 50.00 positron emission tomography 15 32.68 Breakthrough pain 5 22.12 Analgesic 6 21.12 Pain management 1 11.04 Spinal cord 20 5.00

Disease Link Frequency Relevance Heat Osteoporosis 7 100.00 Cancer 86 99.14 Hypercalcemia 2 89.44 Bone Cancer 38 83.64 Pain 59 77.64 Disease 1 66.40 Intractable Pain 2 57.92 Aggression 3 54.12 Metastasis 20 51.52 Embolism 1 49.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The tumor releases osteoclast maturation factors or stimulates osteoblast secretion of RANKL and down-regulation of osteoprotegerin, resulting in dominant resorptive activity [9], [84], [85].

Positive_regulation (stimulates) of Negative_regulation (regulation) of osteoprotegerin in osteoblast associated with cancer and osteoporosis

1) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2966439 Disease Relevance 1.34 Pain Relevance 0.45

General Comments

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