INT34143

Context Info Confidence 0.44 First Reported 1987 Last Reported 2010 Negated 4 Speculated 3 Reported most in Body Documents 14 Total Number 18 Disease Relevance 4.83 Pain Relevance 0.58

signal transduction (IMPA1) mitochondrion (IMPA1) nucleolus (IMPA1) nucleus (IMPA1) cytoplasm (IMPA1)

Anatomy Link Frequency foot 4 muscle 2 brain 1 IMPA1 (Homo sapiens)

Pain Link Frequency Relevance Heat imagery 13 99.80 ischemia 17 98.24 tricyclic antidepressant 1 92.96 anesthesia 30 79.76 Lasting pain 1 77.16 antidepressant 2 75.00 Morphine 14 29.04 ketamine 7 20.40 fibrosis 21 16.00 Inflammation 10 5.00

Disease Link Frequency Relevance Heat Stress 77 100.00 Left Ventricular Dysfunction 28 99.00 Cv Unclassified Under Development 20 98.24 Arrhythmias 2 Under Development 7 97.00 Heart Disease 14 96.28 Hypertension 21 95.72 Myocardial Infarction 62 95.64 Coronary Heart Disease 46 95.00 Diabetic Cardiomyopathies 7 93.68 Fibrosis 28 89.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The goals of this study were: [1] to determine the effects of increased contractility on IMP and its components; and [2] to determine whether digoxin, a weak inotrope without an adverse survival benefit, affects IMP and its components.

Spec (whether) Regulation (affects) of IMP

1) Confidence 0.44 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1654186 Disease Relevance 0.46 Pain Relevance 0.07

No significant changes in ATP and IMP muscle concentrations were observed during exercise despite the fact that at the end of the exercise the demand for ATP was at its highest.

Neg (No) Regulation (changes) of IMP in muscle

2) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957441 Disease Relevance 0 Pain Relevance 0

The finding of a lack of IMP accumulation or ATP decrease during exercise in the present study is consistent with other studies showing that no changes in muscle IMP, ATP or NH3 occur until PCr levels have significantly decreased to values below ?

Neg (no) Regulation (changes) of IMP in muscle

3) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957441 Disease Relevance 0.14 Pain Relevance 0

Total changes in IMP and EMG amplitude during 1 min isometric contraction were linearly interrelated (r = 0.747, p < 0.0001).

Regulation (changes) of IMP

4) Confidence 0.23 Published 2005 Journal Physiol Meas Section Abstract Doc Link 16311444 Disease Relevance 0.08 Pain Relevance 0.08

Limited work has been performed assessing the effect of contractility on IMP and its components with LV dysfunction without the obfuscating effects of intraventricular conduction delay or ischemic provocation [6,7].

Regulation (effect) of IMP associated with arrhythmias 2 under development

5) Confidence 0.19 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1654186 Disease Relevance 0.37 Pain Relevance 0.05

Although clinical studies [6,7] have been performed assessing the effect of dobutamine stress on IMP with LV dysfunction, the focus has been on ischemia or contractile reserve.

Regulation (effect) of IMP associated with stress and ischemia

6) Confidence 0.19 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1654186 Disease Relevance 0.40 Pain Relevance 0.05

Finally, it is not clear that dobutamine or digoxin might have similar effects on IMP and its components with more severe LV dysfunction.

Spec (might) Regulation (effects) of IMP

7) Confidence 0.19 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1654186 Disease Relevance 0.55 Pain Relevance 0.05

As the LV ejection fraction was <40% (moderate LV dysfunction) in several animals, and the responses of IMP and ICT were uniform in most dogs, it might be reasonable to expect that inotropic stimulation with more severe LV dysfunction might produce similar responses in IMP and ICT.

Spec (might) Regulation (responses) of IMP

8) Confidence 0.19 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1654186 Disease Relevance 0.61 Pain Relevance 0

As the index of myocardial performance has been shown to be preload and afterload dependent, the effect of altering contractility on IMP and its components with left ventricular dysfunction has been incompletely delineated.

Regulation (altering) of IMP associated with left ventricular dysfunction

9) Confidence 0.19 Published 2006 Journal Cardiovasc Ultrasound Section Abstract Doc Link PMC1654186 Disease Relevance 0.45 Pain Relevance 0

As the LV ejection fraction was <40% (moderate LV dysfunction) in several animals, and the responses of IMP and ICT were uniform in most dogs, it might be reasonable to expect that inotropic stimulation with more severe LV dysfunction might produce similar responses in IMP and ICT.

Regulation (responses) of IMP

10) Confidence 0.19 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1654186 Disease Relevance 0.62 Pain Relevance 0

Its high brain affinity has been used to advantage for cerebral perfusion imaging, but the effects of drugs on IMP distribution could affect its utility.

Regulation (effects) of IMP in brain associated with imagery

11) Confidence 0.14 Published 1987 Journal J. Nucl. Med. Section Abstract Doc Link 3029345 Disease Relevance 0 Pain Relevance 0.28

This was done in two ways: first, r was calculated between the 'absolute' foot rotation angle in each condition and the corresponding PFM and IMP values obtained.

Regulation (values) of IMP in foot

12) Confidence 0.10 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2733135 Disease Relevance 0 Pain Relevance 0

Results of the ANOVAs performed on selected FM variables (table 2) reveal that PFM and IMP were significantly affected by foot rotation condition.

Regulation (affected) of IMP in foot

13) Confidence 0.10 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2733135 Disease Relevance 0 Pain Relevance 0

Second, r was calculated between the relative change in foot rotation angle in the INT and EXT foot rotation conditions and the corresponding change in PFM and IMP with respect to normal walking.

Regulation (change) of IMP in foot

14) Confidence 0.10 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2733135 Disease Relevance 0 Pain Relevance 0

However, it is interesting to note that changes in either absolute or relative PFM and IMP were not particularly dependent on the absolute or relative foot rotation angle adopted during stance.

Regulation (changes) of IMP in foot

15) Confidence 0.10 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2733135 Disease Relevance 0.07 Pain Relevance 0

In 20 HT adult recipients with grade 3A cellular rejection, there was a mean increase of IMP by 98% (p < 0.0001) during the AAR episode and a decrease to its baseline values after treatment; in addition, the change in IMP was independent of both baseline EF and EF changes during AAR [23].

Regulation (change) of IMP

16) Confidence 0.03 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2249582 Disease Relevance 0.16 Pain Relevance 0

It is possible that during AAR IVRT fall is counterbalanced by ICT prolongation and this may result in no significant change of IMP.

Neg (no) Regulation (change) of IMP

17) Confidence 0.01 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2249582 Disease Relevance 0.53 Pain Relevance 0

However, in another experience [24], the comparison of intra-recipient changes in Doppler intervals between rejection and non-rejection states demonstrated prolongation of IVRT and shortening of ICT during AAR, with no change in the IMP.

Neg (no) Regulation (change) of IMP

18) Confidence 0.01 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2249582 Disease Relevance 0.39 Pain Relevance 0

General Comments

This test has worked.