INT34144

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Context Info
Confidence 0.37
First Reported 1987
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.88
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IMPA1) mitochondrion (IMPA1) nucleolus (IMPA1)
nucleus (IMPA1) cytoplasm (IMPA1)
Anatomy Link Frequency
brain 1
synovium 1
lung 1
IMPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 23 91.48 High High
anesthesia 4 90.96 High High
tricyclic antidepressant 2 79.80 Quite High
antidepressant 4 75.00 Quite High
imagery 2 74.00 Quite High
corticosteroid 3 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
Osteoarthritis 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 25 100.00 Very High Very High Very High
Infection 3 97.80 Very High Very High Very High
INFLAMMATION 25 91.48 High High
Hypersensitivity 1 90.32 High High
Recurrence 3 83.20 Quite High
Disease 7 48.00 Quite Low
Thrombocytopenia 1 22.00 Low Low
Hemolytic Anemia 4 5.00 Very Low Very Low Very Low
Osteoarthritis 3 5.00 Very Low Very Low Very Low
Lymphadenopathy 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In rabbits, simultaneous or postloading doses of imipramine resulted in release of IMP from the lung with an increase in brain activity.
Localization (release) of IMP in brain
1) Confidence 0.37 Published 1987 Journal J. Nucl. Med. Section Abstract Doc Link 3029345 Disease Relevance 0 Pain Relevance 0.31
In rats, preloading doses of imipramine depressed lung uptake but did not result in increased brain IMP uptake; postloading doses of imipramine did not release IMP from the lung.
Neg (not) Localization (release) of IMP in lung
2) Confidence 0.37 Published 1987 Journal J. Nucl. Med. Section Abstract Doc Link 3029345 Disease Relevance 0 Pain Relevance 0.32
(Anaplasma spp.) were reported as a cause of type II IMPA in dogs [13] where it is assumed that the infectious process provides an antigenic source for immune complex formation, and either the antigen or circulating complexes are deposited within the synovium to initiate inflammation by a type III hypersensitivity reaction [14].
Localization (cause) of IMPA in synovium associated with inflammation, hypersensitivity and arthritis
3) Confidence 0.07 Published 2006 Journal Acta Vet Scand Section Body Doc Link PMC1553462 Disease Relevance 0.88 Pain Relevance 0.14

General Comments

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