INT341563

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.58
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell motility (ITGB4) cell adhesion (ITGB4) plasma membrane (ITGB4)
Anatomy Link Frequency
endothelial cells 1
ITGB4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 9 98.48 Very High Very High Very High
Inflammation 105 98.08 Very High Very High Very High
agonist 78 91.40 High High
COX2 3 83.52 Quite High
Arthritis 15 60.16 Quite High
antagonist 12 15.60 Low Low
chemokine 3 8.96 Low Low
Inflammatory mediators 12 5.00 Very Low Very Low Very Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
spastic colon 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 60 99.84 Very High Very High Very High
Carcinoma 3 99.24 Very High Very High Very High
INFLAMMATION 126 98.08 Very High Very High Very High
Disease 15 88.00 High High
Wound Healing 3 74.16 Quite High
Targeted Disruption 6 70.48 Quite High
Breast Cancer 3 70.20 Quite High
Metastasis 12 63.76 Quite High
Inflammatory Bowel Disease 3 61.24 Quite High
Arthritis 15 60.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Integrin beta 4 (ITGB4) is a laminin receptor that is upregulated in tumor cells and angiogenic endothelial cells [45].
Positive_regulation (upregulated) of ITGB4 in endothelial cells associated with cancer
1) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.74 Pain Relevance 0.03
PAR-2 activation up-regulated four genes more than 5 fold (DUSP6, WWOX, AREG, SERPINB2) and down-regulated another six genes more than 3 fold (TXNIP, RARG, ITGB4, CTSD, MSC and TM4SF15).
Positive_regulation (activation) of ITGB4
2) Confidence 0.26 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2970545 Disease Relevance 0.66 Pain Relevance 0.32
Tumour and growth factor genes like WWOX, p73, ITGB4 and AREG were strongly up-regulated by PAR2 activation, supporting roles for PAR2 in proliferation, tumour growth and, perhaps surprisingly, also tumour suppression.
Positive_regulation (regulated) of ITGB4 associated with cancer
3) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 1.18 Pain Relevance 0.24

General Comments

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