INT342358

Context Info Confidence 0.37 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0

cytoplasm (Irs1, Erap1) endoplasmic reticulum (Erap1) signal transducer activity (Irs1) cytosol (Irs1) signal transduction (Irs1) peptidase activity (Erap1)

Anatomy Link Frequency immune system 2 Irs1 (Mus musculus) Erap1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 12 5.00 anesthesia 4 5.00 Central nervous system 2 5.00 ketamine 2 5.00 ischemia 2 5.00 Inflammatory response 2 5.00

Disease Link Frequency Relevance Heat Aging 98 50.00 Sprains And Strains 4 11.68 Stress 28 5.00 Disease 22 5.00 Age-related Macular Degeneration 18 5.00 INFLAMMATION 14 5.00 Retinal Diseases 12 5.00 Retina Disease 6 5.00 Apoptosis 6 5.00 Hypoxia 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The list of validated genes includes those associated with retinoic acid receptor (RAR) signaling - retinol dehydrogenase 9 (Rdh9); immune system regulation - histocompatibility 2 K1, K region (H2-K1), interferon regulatory factor 6 (Irf6), and endoplasmic reticulum aminopeptidase 1 (Erap1); lipid and insulin metabolism - stearoyl coenzyme A desaturase (Scd1), oxysterol binding protein-like 1A (Osbpl1a), and insulin receptor substrate 1 (Irs1); and two genes that have not yet been characterized (Ai117581, Riken C030034E14).

insulin receptor substrate 1 Binding (associated) of Erap1 in immune system

1) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975639 Disease Relevance 0 Pain Relevance 0

The list of validated genes includes those associated with retinoic acid receptor (RAR) signaling - retinol dehydrogenase 9 (Rdh9); immune system regulation - histocompatibility 2 K1, K region (H2-K1), interferon regulatory factor 6 (Irf6), and endoplasmic reticulum aminopeptidase 1 (Erap1); lipid and insulin metabolism - stearoyl coenzyme A desaturase (Scd1), oxysterol binding protein-like 1A (Osbpl1a), and insulin receptor substrate 1 (Irs1); and two genes that have not yet been characterized (Ai117581, Riken C030034E14).

insulin receptor substrate 1 Binding (associated) of reticulum aminopeptidase 1 in immune system

2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975639 Disease Relevance 0 Pain Relevance 0

General Comments

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