INT342960

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2007
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.39
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (CAPN3) protein complex assembly (CAPN3) protein complex (CAPN3)
cytoplasm (CAPN3) signal transducer activity (CAPN3) cytosol (CAPN3)
CAPN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 62.84 Quite High
ischemia 6 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autolysis 15 99.74 Very High Very High Very High
Pain 6 62.84 Quite High
Targeted Disruption 3 27.32 Quite Low
Muscular Dystrophy 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Brain Hemorrhage 3 5.00 Very Low Very Low Very Low
Embryonic Lethality 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is also possible that the protease activity of p94 was not responsible for increasing the abundance of other proteins.
Neg (not) Spec (possible) Regulation (responsible) of p94
1) Confidence 0.45 Published 2007 Journal Biotechnology Journal Section Body Doc Link PMC2978325 Disease Relevance 0.11 Pain Relevance 0.06
Thus, it was difficult to extract proteins whose increase in abundance was dependent on p94 protease activity.
Regulation (dependent) of p94
2) Confidence 0.45 Published 2007 Journal Biotechnology Journal Section Body Doc Link PMC2978325 Disease Relevance 0.12 Pain Relevance 0.06
While autolysis causes down-regulation of p94 as a whole molecule, proteolysis of vimentin would confer other properties on certain parts of the molecule.
Regulation (regulation) of p94 associated with autolysis
3) Confidence 0.45 Published 2007 Journal Biotechnology Journal Section Body Doc Link PMC2978325 Disease Relevance 0.16 Pain Relevance 0.06

General Comments

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