INT342986

Context Info Confidence 0.14 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.39 Pain Relevance 0.84

extracellular space (IL6) aging (IL6) extracellular region (IL6) nucleolus (PTAFR) plasma membrane (PTAFR) nucleus (PTAFR)

Anatomy Link Frequency muscle 2 PTAFR (Homo sapiens) IL6 (Homo sapiens)

Pain Link Frequency Relevance Heat substance P 27 96.36 chemokine 9 93.84 qutenza 6 91.48 agonist 2 91.08 calcitonin gene related peptide 16 84.32 tetrodotoxin 3 83.20 Inflammation 37 75.00 TRP channel 2 72.84 Inflammatory mediators 14 51.76 antagonist 18 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 48 75.00 Esophageal Disease 22 74.40 Gastroesophageal Reflux Disease 12 64.76 Injury 5 5.00 Acid Reflux 3 5.00 Neurogenic Inflammation 2 5.00 Disease 2 5.00 Ileitis 1 5.00 Hyperplasia 1 5.00 Death 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In circular muscle, PAF causes production of IL-6, and IL-6 causes production of additional H2O2, through activation of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidases.

PAF Positive_regulation (causes) of Gene_expression (production) of IL-6 in muscle

1) Confidence 0.14 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Abstract Doc Link PMC2978390 Disease Relevance 0.39 Pain Relevance 0.84

General Comments

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