INT34312

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Context Info
Confidence 0.46
First Reported 1987
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.97
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CRH) extracellular space (CRH) extracellular region (CRH)
response to stress (CRH)
Anatomy Link Frequency
hypothalamus 2
neurons 2
immune system 2
hippocampus 2
CRH (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 24 99.84 Very High Very High Very High
antidepressant 2 99.60 Very High Very High Very High
narcan 6 99.18 Very High Very High Very High
Inflammation 24 98.84 Very High Very High Very High
antagonist 2 94.40 High High
Catecholamine 2 86.56 High High
depression 9 86.16 High High
addiction 3 86.08 High High
drug abuse 3 84.96 Quite High
medulla 18 80.96 Quite High
Disease Link Frequency Relevance Heat
Stress 172 99.50 Very High Very High Very High
INFLAMMATION 23 98.84 Very High Very High Very High
Disease 56 88.32 High High
Anxiety Disorder 10 86.88 High High
Depression 13 86.16 High High
Drug Dependence 3 84.96 Quite High
Pre-term Labor 2 72.32 Quite High
Syndrome 17 69.20 Quite High
Enteropathy 1 67.52 Quite High
Inflammatory Bowel Disease 1 66.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition Inhibition of the ACTH response occurs through the glucocorticoids binding to receptors in the hippocampus, which control CRH production and limiting the period of exposure to the stress response, therefore minimizing the catabolic immunosuppressive and anti-reproductive effects of glucocorticoids [6].
Regulation (control) of Gene_expression (production) of CRH in hippocampus associated with stress and hippocampus
1) Confidence 0.46 Published 2006 Journal Chiropr Osteopat Section Body Doc Link PMC1629015 Disease Relevance 0.26 Pain Relevance 0.13
Multiple research groups have demonstrated during the last decade the expression of the CRF peptides and their receptors in several components of the immune system and their participation in the ad hoc regulation of inflammatory phenomena.
Regulation (participation) of Gene_expression (expression) of CRF in immune system associated with inflammation
2) Confidence 0.44 Published 2005 Journal Curr. Med. Chem. Section Abstract Doc Link 15974983 Disease Relevance 1.39 Pain Relevance 0.50
Via a delicate negative feedback loop, glucocorticoids control the termination of the stress response via inhibitory control of the production and release of CRH and ACTH at the level of the hypothalamus and pituitary respectively, via transmitter systems projecting to the hypothalamus [56].
Regulation (control) of Gene_expression (production) of CRH in hypothalamus associated with stress
3) Confidence 0.39 Published 2006 Journal Chiropr Osteopat Section Body Doc Link PMC1629015 Disease Relevance 0.17 Pain Relevance 0.12
After 4 mg of naloxone in the morning, no significant hormonal changes in response to hCRH were observed.
Regulation (response) of Gene_expression (changes) of hCRH associated with narcan
4) Confidence 0.36 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 3033966 Disease Relevance 0 Pain Relevance 0.51
In order to test if antidepressant drugs can directly influence corticotropin-releasing hormone (CRH) gene expression, their effect on CRH gene promoter activity was evaluated in neuro-2A cells stably transfected with a human CRH - chloramphenicol acetyl-transferase plasmid.
Regulation (influence) of Gene_expression (expression) of CRH associated with antidepressant
5) Confidence 0.27 Published 2002 Journal Pol J Pharmacol Section Abstract Doc Link 12866730 Disease Relevance 0 Pain Relevance 0.19
The PVN is not only abundant of CRH neurons but also the main source for OT synthesis.
Regulation (abundant) of Gene_expression (neurons) of CRH in neurons
6) Confidence 0.11 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0.15 Pain Relevance 0.03

General Comments

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