INT343163

Context Info Confidence 0.08 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.50 Pain Relevance 0

small molecule metabolic process (ACSL4, PTGS2) endoplasmic reticulum (ACSL4, PTGS2) mitochondrion (ACSL4) peroxisome (ACSL4) enzyme binding (PTGS2) protein complex (PTGS2)

Anatomy Link Frequency MDA-MB-231 2 ACSL4 (Homo sapiens) PTGS2 (Homo sapiens)

Pain Link Frequency Relevance Heat COX2 1 5.00 COX-2 inhibitor 1 5.00 cINOD 1 5.00

Disease Link Frequency Relevance Heat Breast Cancer 37 98.40 Hepatocellular Cancer 5 84.56 Aggression 6 72.24 Cancer 14 25.00 Injury 21 5.00 Apoptosis 12 5.00 Colon Cancer 9 5.00 Targeted Disruption 4 5.00 Wound Healing 3 5.00 Metastasis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The first novel finding is that ACSL4 regulates the expression of cyclooxygenase-2 (COX-2) and the production of prostaglandin in MDA-MB-231 cells.

ACSL4 Regulation (regulates) of Gene_expression (expression) of cyclooxygenase-2 in MDA-MB-231

1) Confidence 0.08 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2978721 Disease Relevance 0.50 Pain Relevance 0

General Comments

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