INT3434

Context Info Confidence 0.76 First Reported 1978 Last Reported 1999 Negated 1 Speculated 0 Reported most in Abstract Documents 6 Total Number 7 Disease Relevance 0.16 Pain Relevance 3.21

extracellular region (Vip, Prl)

Anatomy Link Frequency pituitary 4 hypothalamus 2 Vip (Rattus norvegicus) Prl (Rattus norvegicus)

Pain Link Frequency Relevance Heat Opioid 8 100.00 Dopamine 11 99.88 Dynorphin 20 99.68 narcan 8 98.84 Kappa opioid receptor 6 98.78 opiate 4 98.20 Central nervous system 2 97.28 antagonist 11 95.08 agonist 2 93.44 Enkephalin 4 90.72

Disease Link Frequency Relevance Heat Stress 2 90.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results suggest that VIP stimulates rat PRL secretion, at least in part, through activation of an opiate receptor in the central nervous system and by blocking the inhibitory action of a dopaminergic mechanism at the pituitary level.

VIP Positive_regulation (stimulates) of Localization (secretion) of PRL in pituitary associated with central nervous system and opiate

1) Confidence 0.76 Published 1978 Journal Endocrinology Section Abstract Doc Link 744101 Disease Relevance 0 Pain Relevance 0.53

Vasoactive intestinal peptide is a physiological mediator of prolactin release in the rat.

intestinal peptide Positive_regulation (mediator) of Localization (release) of prolactin

2) Confidence 0.66 Published 1985 Journal Endocrinology Section Title Doc Link 4038645 Disease Relevance 0.16 Pain Relevance 0.10

In in vitro experiments, VIP alone did not stimulate PRL release from cultured pituitary cells, but it significantly attenuated the inhibitory action of dopamine, which was not blocked by naloxone.

VIP Neg (not) Positive_regulation (stimulate) of Localization (release) of PRL in pituitary associated with dopamine and narcan

3) Confidence 0.45 Published 1978 Journal Endocrinology Section Abstract Doc Link 744101 Disease Relevance 0 Pain Relevance 0.53

VIP stimulated prolactin secretion from incubated rat hemipituitaries.

VIP Positive_regulation (stimulated) of Localization (secretion) of prolactin

4) Confidence 0.38 Published 1980 Journal Neuroendocrinology Section Abstract Doc Link 7413020 Disease Relevance 0 Pain Relevance 0.06

The results suggest a role for VIP, but not TRH, in opioid peptide stimulated release of prolactin.

VIP Positive_regulation (role) of Localization (release) of prolactin associated with opioid

5) Confidence 0.36 Published 1987 Journal Life Sci. Section Abstract Doc Link 3102870 Disease Relevance 0 Pain Relevance 0.53

These data show that: (1) dynorphin stimulates PRL secretion by activating kappa opioid receptors in the avian hypothalamus, and (2) dynorphin, 5-HT, DA, and VIP stimulate avian PRL secretion via a common pathway expressing kappa opioid, serotonergic, dopaminergic, and VIPergic receptors at synapses arranged serially in that functional order, with the VIPergic system as the final mediator (releasing factor).

VIP Positive_regulation (stimulate) of Localization (secretion) of PRL in hypothalamus associated with dopamine, dynorphin, kappa opioid receptor and opioid

6) Confidence 0.14 Published 1999 Journal Neuroendocrinology Section Abstract Doc Link 10567857 Disease Relevance 0 Pain Relevance 0.92

This study tested the hypothesis that centrally infused dynorphin requires an intact vasoactive intestinal peptide (VIP) system in order to stimulate turkey PRL secretion.

vasoactive intestinal peptide Positive_regulation (stimulate) of Localization (secretion) of PRL associated with dynorphin

7) Confidence 0.13 Published 1999 Journal Neuroendocrinology Section Abstract Doc Link 10567857 Disease Relevance 0 Pain Relevance 0.54

General Comments

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