INT343638

Context Info Confidence 0.00 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

signal transduction (Grm1) plasma membrane (Grm1) nucleus (Grm1) signal transducer activity (Grm1)

Adp (Mus musculus) Grm1 (Mus musculus)

Pain Link Frequency Relevance Heat Glutamate 7 50.00 Pyramidal cell 15 39.44 Action potential 22 5.00 Calcium channel 14 5.00 addiction 8 5.00 Glutamate receptor 6 5.00 antagonist 4 5.00 Hippocampus 4 5.00 Neuronal excitability 3 5.00 conotoxin 2 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 7 5.00 Disease 2 5.00 Sprains And Strains 1 5.00 Intellectual Impairment 1 5.00 Neurological Disease 1 5.00 Epilepsy 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Indeed, the pharmacology suggests that the medium ADP requires activation of mGluR5 (and to a lesser extent mGluR1) and activation of G proteins (likely Gq) and PLC.

ADP Positive_regulation (requires) of Positive_regulation (activation) of mGluR1

1) Confidence 0.00 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0

General Comments

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