INT343836

Context Info Confidence 0.02 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.80 Pain Relevance 0.14

transport (LBP) DNA binding (IRF6) cytoplasm (IRF6) cytosol (IRF6) lipid binding (LBP) extracellular space (LBP)

IRF6 (Homo sapiens) LBP (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 94 78.16 fibrosis 36 56.88 Inflammation 132 49.64 agonist 108 5.00 Inflammatory response 30 5.00 chemokine 20 5.00 tolerance 14 5.00 Bile 10 5.00 metalloproteinase 10 5.00 alcohol 8 5.00

Disease Link Frequency Relevance Heat Fibrosis 48 82.20 Apoptosis 26 81.48 Injury 62 61.56 Cirrhosis 122 54.64 INFLAMMATION 160 49.64 Liver Disease 12 43.64 Alcoholic Liver Diseases 4 41.28 Hepatitis Virus Infection 4 39.52 Disease 16 32.24 Infection 24 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

For example, for the initiation of LPS to activate intracellular TLR4 signaling, the ligand first interacts with circulating LPS-binding protein (LBP) along with three LRR domain-containing proteins, TLR4 and the two co-receptors CD14 and myeloid differentiation protein (MD)2, together comprising the LPS receptor complex [5].

LPS Binding (interacts) of LPS-binding

1) Confidence 0.02 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.40 Pain Relevance 0.07

For example, for the initiation of LPS to activate intracellular TLR4 signaling, the ligand first interacts with circulating LPS-binding protein (LBP) along with three LRR domain-containing proteins, TLR4 and the two co-receptors CD14 and myeloid differentiation protein (MD)2, together comprising the LPS receptor complex [5].

LPS Binding (interacts) of LBP

2) Confidence 0.02 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.40 Pain Relevance 0.07

General Comments

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