INT343909

Context Info Confidence 0.04 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 3.49 Pain Relevance 0.91

signal transduction (TLR4) plasma membrane (TLR4) intracellular (TLR4) cytoplasm (TLR4)

IgG (Mus musculus) TLR4 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammatory response 30 97.40 Bile 10 90.28 Inflammation 132 88.72 ischemia 8 81.84 alcohol 8 81.76 cytokine 94 72.28 agonist 108 66.40 fibrosis 36 5.00 chemokine 20 5.00 tolerance 14 5.00

Disease Link Frequency Relevance Heat Primary Sclerosing Cholangitis 2 99.98 Biliary Liver Cirrhosis 8 97.68 INFLAMMATION 160 97.04 Hepatitis 10 91.64 Liver Disease 12 82.88 Cv Unclassified Under Development 6 81.84 Reperfusion Injury 22 81.12 Injury 62 80.36 Organ Transplantation 2 77.52 Hemorrhagic Shock 2 75.68

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Stimulation of BECs with primary sclerosing cholangitis IgG, but not control IgG, induces expression of TLR4 and TLR9, and specific phosphorylation of both ERK, and the transcription factors ELK-1 and NF-?

IgG Positive_regulation (induces) of Gene_expression (expression) of TLR4 associated with primary sclerosing cholangitis

1) Confidence 0.04 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.74 Pain Relevance 0.45

Stimulation of BECs with primary sclerosing cholangitis IgG, but not control IgG, induces expression of TLR4 and TLR9, and specific phosphorylation of both ERK, and the transcription factors ELK-1 and NF-?

IgG Positive_regulation (induces) of Gene_expression (expression) of TLR4 associated with primary sclerosing cholangitis

2) Confidence 0.04 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.75 Pain Relevance 0.46

General Comments

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