INT343913

Context Info Confidence 0.19 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.92 Pain Relevance 0.54

nucleus (FOS, Smad3) nucleoplasm (FOS) transport (Smad3) aging (FOS) intracellular (Smad3) DNA binding (Smad3)

FOS (Homo sapiens) Smad3 (Mus musculus)

Pain Link Frequency Relevance Heat metalloproteinase 10 91.20 cytokine 94 53.08 Inflammation 132 52.68 agonist 108 5.00 fibrosis 36 5.00 Inflammatory response 30 5.00 chemokine 20 5.00 tolerance 14 5.00 Bile 10 5.00 alcohol 8 5.00

Disease Link Frequency Relevance Heat Cirrhosis 122 89.16 Fibrosis 48 79.12 Stress 18 59.72 Viral Infection 4 54.40 INFLAMMATION 160 52.68 Injury 62 50.00 Apoptosis 26 10.88 Infection 24 5.00 Reperfusion Injury 22 5.00 Hepatitis C Virus Infection 20 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Examples of these crucial combinations include the cooperation of Smad3/4 complex with AP-1 in mediating TGF-?

AP-1 Binding (complex) of Smad3

1) Confidence 0.19 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.46 Pain Relevance 0.27

Examples of these crucial combinations include the cooperation of Smad3/4 complex with AP-1 in mediating TGF-?

AP-1 Binding (complex) of Smad3

2) Confidence 0.19 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.46 Pain Relevance 0.27

General Comments

This test has worked.