INT344334

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Context Info
Confidence 0.36
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 2.76
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PDPN) signal transduction (PDPN) cell morphogenesis (PDPN)
plasma membrane (PDPN) embryo development (PDPN) cell cycle (PDPN)
PDPN (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 6 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 6 95.24 Very High Very High Very High
Skin Cancer 102 95.12 Very High Very High Very High
Cancer 492 91.64 High High
Malignant Neoplastic Disease 84 91.44 High High
Metastasis 150 79.12 Quite High
Adenocarcinoma 6 78.80 Quite High
Lung Cancer 6 76.16 Quite High
Small Cell Lung Carcinoma 12 5.00 Very Low Very Low Very Low
Germ Cell And Embryonal Neoplasms 6 5.00 Very Low Very Low Very Low
Respiratory Failure 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further validate whether the increased activation of JNK-mediated downregulation of VEGF-C is dependent on podoplanin, the levels of phosphorylated JNK and VEGF-C mRNA were examined using siRNA methods.
Spec (whether) Negative_regulation (downregulation) of podoplanin
1) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.05 Pain Relevance 0
Podoplanin-induced VEGF-C downregulation is mediated by an increase in the level of activated JNK in LSCCs
Negative_regulation (downregulation) of Podoplanin
2) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.40 Pain Relevance 0
Taken together, these findings suggest that JNK is a key pathway for inducing podoplanin-mediated downregulation of the VEGF-C gene in LSCCs.


Negative_regulation (downregulation) of podoplanin
3) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.56 Pain Relevance 0
Therefore, we are concerned about the interpretation of podoplanin's functions in several past studies.
Negative_regulation (interpretation) of podoplanin
4) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.79 Pain Relevance 0
The former effect of exogenous podoplanin was impaired by treatment with either JNK inhibitor sp600125 or podoplanin-siRNA, and the latter effect was impaired by treatment with podoplanin-siRNA, suggesting that podoplanin was able to activate JNK, thereby downregulating VEGF-C gene expression in LSCCs (podoplanin-JNK-VEGF-C axis).
Negative_regulation (impaired) of podoplanin
5) Confidence 0.31 Published 2010 Journal Mol Cancer Section Abstract Doc Link PMC2987985 Disease Relevance 0.88 Pain Relevance 0
Taken together, these findings suggested that the podoplanin-mediated increase in the level of activated JNK was a downregulation signal for the VEGF-C gene in EBC-1 cells.
Negative_regulation (downregulation) of podoplanin
6) Confidence 0.31 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.08 Pain Relevance 0

General Comments

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