INT345077

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.59
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Lpar4) signal transduction (Lpar4) plasma membrane (Lpar4)
signal transducer activity (Lpar4)
Anatomy Link Frequency
platelets 1
Lpar4 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 60 54.28 Quite High
antagonist 60 5.00 Very Low Very Low Very Low
fibrosis 36 5.00 Very Low Very Low Very Low
Neuropathic pain 32 5.00 Very Low Very Low Very Low
dorsal root ganglion 16 5.00 Very Low Very Low Very Low
Pain 16 5.00 Very Low Very Low Very Low
metalloproteinase 16 5.00 Very Low Very Low Very Low
Potency 12 5.00 Very Low Very Low Very Low
alcohol 8 5.00 Very Low Very Low Very Low
Multiple sclerosis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alopecia 12 89.80 High High
Coronary Artery Disease 4 83.52 Quite High
Targeted Disruption 60 77.76 Quite High
Shock 4 58.76 Quite High
Neuroblastoma 4 56.72 Quite High
Cancer 96 31.52 Quite Low
Hypotrichosis 12 9.76 Low Low
Ovarian Cancer 64 5.00 Very Low Very Low Very Low
Apoptosis 60 5.00 Very Low Very Low Very Low
Metastasis 40 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The better-characterized LPA-sensitive members of this cluster are P2Y9/GPR23/LPA4 (this will be abbreviated as LPA4) (Noguchi et al., 2003; Yanagida et al., 2007) and GPR92/LPA5 (this will be abbreviated as LPA5) (Kotarsky et al., 2006; Lee et al., 2006; Williams et al., 2009; Yin et al., 2009).
Localization (abbreviated) of LPA4
1) Confidence 0.33 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0 Pain Relevance 0
The P2Y10 gene is localized to region 21.1 of the X chromosome near the gene for the LPA4 receptor.
Localization (localized) of LPA4 receptor
2) Confidence 0.33 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.32 Pain Relevance 0.03
The better-characterized LPA-sensitive members of this cluster are P2Y9/GPR23/LPA4 (this will be abbreviated as LPA4) (Noguchi et al., 2003; Yanagida et al., 2007) and GPR92/LPA5 (this will be abbreviated as LPA5) (Kotarsky et al., 2006; Lee et al., 2006; Williams et al., 2009; Yin et al., 2009).
Localization (abbreviated) of LPA4
3) Confidence 0.33 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0 Pain Relevance 0
In patients whose platelets do not respond to LPA, LPA4 mRNA is increased sixfold over platelets from patients that are LPA-responsive.
Neg (not) Localization (respond) of LPA4 in platelets
4) Confidence 0.15 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.27 Pain Relevance 0

General Comments

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