INT345105

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Context Info
Confidence 0.28
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.16
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lpar1) plasma membrane (Lpar1) cytoplasm (Lpar1)
signal transducer activity (Lpar1)
Lpar1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 15 89.76 High High
alcohol 2 74.20 Quite High
antagonist 15 67.92 Quite High
fibrosis 9 5.00 Very Low Very Low Very Low
Neuropathic pain 8 5.00 Very Low Very Low Very Low
dorsal root ganglion 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 10 52.84 Quite High
Cancer 24 52.40 Quite High
Ovarian Cancer 16 5.00 Very Low Very Low Very Low
Targeted Disruption 15 5.00 Very Low Very Low Very Low
Apoptosis 15 5.00 Very Low Very Low Very Low
Neuropathic Pain 10 5.00 Very Low Very Low Very Low
Infection 7 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Fibrosis 6 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
50 nM EC50) without activation of LPA1,2,3,4 (in fact these reagents are weak inhibitors of LPA2,3,4 with IC50 values in the mid-micromolar range) (Williams et al., 2009).
Negative_regulation (inhibitors) of Neg (without) Positive_regulation (activation) of LPA1
1) Confidence 0.28 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.16 Pain Relevance 0.21

General Comments

This test has worked.

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