INT345209

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.88
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Repin1, Trib3) nucleolus (Trib3) intracellular (Repin1)
enzyme binding (Trib3) DNA binding (Repin1) kinase activity (Trib3)
Anatomy Link Frequency
midbrain 2
Repin1 (Rattus norvegicus)
Trib3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
midbrain 5 99.60 Very High Very High Very High
Inflammation 4 57.64 Quite High
Glutamate receptor 2 50.00 Quite Low
chemokine 1 45.64 Quite Low
Glutamate 28 39.88 Quite Low
agonist 37 5.00 Very Low Very Low Very Low
Dopamine 17 5.00 Very Low Very Low Very Low
GABAergic 9 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
gABA 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 4 98.60 Very High Very High Very High
Death 3 92.16 High High
Parkinson's Disease 18 88.92 High High
Disease 65 67.92 Quite High
INFLAMMATION 4 57.64 Quite High
Gliosis 1 56.96 Quite High
Catalepsy 10 5.00 Very Low Very Low Very Low
Depression 5 5.00 Very Low Very Low Very Low
Dyskinesias 4 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The protective effects of L-AP4 against rotenone toxicity again appeared to involve activation of the MAP kinase pathway since L-AP4 increased activation of the MAP kinase extracellular signal-regulated kinase in these midbrain TH-positive neurone cultures and the protection against rotenone toxicity was blocked by pharmacological inhibition of MAP kinase kinase (Jiang et al., 2006).
L-AP4 Positive_regulation (increased) of Positive_regulation (activation) of kinase in midbrain associated with toxicity and midbrain
1) Confidence 0.00 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989582 Disease Relevance 0.88 Pain Relevance 0.18

General Comments

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