INT345499

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.65
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PMAIP1) mitochondrion (PMAIP1) nucleus (PMAIP1)
PMAIP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 31.48 Quite Low
peripheral neuropathy 26 5.00 Very Low Very Low Very Low
dexamethasone 20 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Duloxetine 2 5.00 Very Low Very Low Very Low
anticonvulsant 2 5.00 Very Low Very Low Very Low
Gabapentin 2 5.00 Very Low Very Low Very Low
vincristine 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 24 99.70 Very High Very High Very High
Apoptosis 22 97.80 Very High Very High Very High
Stress 2 91.28 High High
Hypoxia 2 86.52 High High
Skin Cancer 2 72.00 Quite High
Death 2 71.56 Quite High
Mantle-cell Lymphoma 2 70.96 Quite High
Adhesions 4 50.80 Quite High
Neuropathic Pain 30 5.00 Very Low Very Low Very Low
Peripheral Neuropathy 26 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, when c-myc levels were decreased by RNA interference, the tumor cell-specific induction of NOXA was abrogated.
Negative_regulation (abrogated) of Positive_regulation (induction) of NOXA associated with cancer
1) Confidence 0.21 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990320 Disease Relevance 0.74 Pain Relevance 0
The induction of NOXA is therefore essential to override high Mcl-1 levels and allow for the activation of the apoptotic machinery in response to bortezomib.72 Also, NOXA’s interaction with anti-apoptotic members of the Bcl-2 family causes release of cytochrome c into the cytosol, leading to the activation of caspases and induction of apoptosis (Figure 8).73
Negative_regulation (override) of Positive_regulation (induction) of NOXA associated with apoptosis
2) Confidence 0.17 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990320 Disease Relevance 0.90 Pain Relevance 0

General Comments

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