INT346231

Context Info Confidence 0.33 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.65 Pain Relevance 0.33

cytosol (MAPK14, MAP2K3) nucleoplasm (MAPK14, MAP2K3) signal transduction (MAPK14, MAP2K3) nucleus (MAPK14) response to stress (MAPK14) cytoplasm (MAPK14)

MAPK14 (Homo sapiens) MAP2K3 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 8 97.72 Osteoarthritis 103 92.12 Inflammation 16 22.64 Arthritis 8 11.92 metalloproteinase 6 5.00 rheumatoid arthritis 4 5.00 Pain 2 5.00 Inflammatory stimuli 1 5.00 Immobilon 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 104 92.12 Stress 1 87.36 INFLAMMATION 14 22.64 Arthritis 9 11.92 Disease 5 5.20 Rheumatoid Arthritis 4 5.00 Targeted Disruption 3 5.00 Pain 1 5.00 Apoptosis 1 5.00 Hypertrophy 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It is also documented in FLS, that MKK3 and MKK6 each form stable complexes with p38-MAPK that can activate transcriptional activities after cytokine exposure.

p38 Binding (complexes) of MKK3 associated with cytokine

1) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.65 Pain Relevance 0.33

General Comments

This test has worked.