INT346234

Context Info Confidence 0.44 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.65 Pain Relevance 0.77

cytosol (MAP2K6, MAPK14) nucleoplasm (MAP2K6, MAPK14) signal transduction (MAP2K6, MAPK14) nucleus (MAP2K6, MAPK14) response to stress (MAP2K6, MAPK14) cytoplasm (MAP2K6, MAPK14)

Anatomy Link Frequency chondrocytes 1 fibroblasts 1 MAP2K6 (Homo sapiens) MAPK14 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 206 99.60 cytokine 16 99.00 Inflammatory stimuli 2 86.04 Inflammation 32 66.36 Arthritis 16 6.36 metalloproteinase 12 5.00 rheumatoid arthritis 8 5.00 Pain 4 5.00 Immobilon 2 5.00 imagery 2 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 208 99.60 Stress 2 98.64 INFLAMMATION 28 85.72 Disease 10 59.72 Arthritis 18 51.96 Rheumatoid Arthritis 8 5.00 Targeted Disruption 6 5.00 Pain 2 5.00 Apoptosis 2 5.00 Hypertrophy 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

activates the p38-MAPK preferentially via the upstream kinase MKK3 compared to MKK6 in human OA chondrocytes.

MKK6 Positive_regulation (activates) of p38 in chondrocytes associated with osteoarthritis

1) Confidence 0.44 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 1.00 Pain Relevance 0.44

For instance, MKK6 is the major activator of p38-MAPK in cells exposed to osmotic stress [13] and MKK3 is required for full activation of p38-MAPK in murine embryonic fibroblasts [38].

MKK6 Positive_regulation (activator) of p38 in fibroblasts associated with stress

2) Confidence 0.44 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.65 Pain Relevance 0.33

General Comments

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