INT346251

Context Info Confidence 0.40 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.08 Pain Relevance 0.45

cytosol (MAP2K3) nucleoplasm (MAP2K3) signal transduction (MAP2K3)

Anatomy Link Frequency chondrocytes 2 MAP2K3 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 103 100.00 Inflammation 16 5.00 cytokine 8 5.00 Arthritis 8 5.00 metalloproteinase 6 5.00 rheumatoid arthritis 4 5.00 Pain 2 5.00 Inflammatory stimuli 1 5.00 Immobilon 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 104 100.00 Targeted Disruption 3 95.80 INFLAMMATION 14 5.00 Arthritis 9 5.00 Disease 5 5.00 Rheumatoid Arthritis 4 5.00 Pain 1 5.00 Apoptosis 1 5.00 Hypertrophy 1 5.00 Frailty 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Transfection of human OA chondrocytes with MKK3 or MKK6-specific siRNAs knocked down the expression of target proteins and inhibited the IL-1?

Negative_regulation (knocked) of Gene_expression (Transfection) of MKK3 in chondrocytes associated with osteoarthritis

1) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 1.08 Pain Relevance 0.45

General Comments

This test has worked.