INT346253

Context Info Confidence 0.47 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 1.79 Pain Relevance 0.87

cytosol (MAP2K3) nucleoplasm (MAP2K3) signal transduction (MAP2K3)

Anatomy Link Frequency chondrocytes 6 MAP2K3 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 309 99.24 cytokine 24 61.12 Inflammation 48 32.08 Arthritis 24 5.00 metalloproteinase 18 5.00 rheumatoid arthritis 12 5.00 Pain 6 5.00 Inflammatory stimuli 3 5.00 Immobilon 3 5.00 imagery 3 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 312 99.24 Stress 3 65.08 Targeted Disruption 9 53.44 Arthritis 27 46.64 INFLAMMATION 42 32.08 Disease 15 31.04 Rheumatoid Arthritis 12 5.00 Pain 3 5.00 Apoptosis 3 5.00 Hypertrophy 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

-induced activation of MKK3 and MKK6 in primary human OA chondrocytes.

Positive_regulation (induced) of Positive_regulation (activation) of MKK3 in chondrocytes associated with osteoarthritis

1) Confidence 0.47 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.49 Pain Relevance 0.24

-induced activation of MKK3 and MKK6 in human OA chondrocytes

Positive_regulation (induced) of Positive_regulation (activation) of MKK3 in chondrocytes associated with osteoarthritis

2) Confidence 0.47 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.60 Pain Relevance 0.30

-induced activation of MKK3 and MKK6 in human OA chondrocytes, cells were pretreated with PE (6.25 to 100 ?

Positive_regulation (induced) of Positive_regulation (activation) of MKK3 in chondrocytes associated with osteoarthritis

3) Confidence 0.47 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.71 Pain Relevance 0.33

General Comments

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