INT346255

Context Info Confidence 0.42 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.38 Pain Relevance 0.53

cytosol (MAP2K3) nucleoplasm (MAP2K3) signal transduction (MAP2K3)

MAP2K3 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 206 98.44 Inflammation 32 57.76 cytokine 16 50.08 Inflammatory stimuli 2 5.04 Arthritis 16 5.00 metalloproteinase 12 5.00 rheumatoid arthritis 8 5.00 Pain 4 5.00 Immobilon 2 5.00 imagery 2 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 208 98.44 Arthritis 18 72.32 INFLAMMATION 28 57.76 Disease 10 56.72 Stress 2 54.04 Rheumatoid Arthritis 8 5.00 Targeted Disruption 6 5.00 Pain 2 5.00 Apoptosis 2 5.00 Hypertrophy 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, treatment with PE affects particularly the activation of MKK3 which in turn has an impact on the activation of p38-MAPK downstream (summarized in Figure 6).

Regulation (affects) of Positive_regulation (activation) of MKK3

1) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.69 Pain Relevance 0.28

Thus, treatment with PE affects particularly the activation of MKK3 which in turn has an impact on the activation of p38-MAPK downstream (summarized in Figure 6).

Regulation (impact) of Positive_regulation (activation) of MKK3

2) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.69 Pain Relevance 0.25

General Comments

This test has worked.