INT346262

Context Info Confidence 0.42 First Reported 2010 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.09 Pain Relevance 0.45

cytosol (MAP2K3) nucleoplasm (MAP2K3) signal transduction (MAP2K3)

MAP2K3 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 103 93.40 Inflammation 16 5.00 cytokine 8 5.00 Arthritis 8 5.00 metalloproteinase 6 5.00 rheumatoid arthritis 4 5.00 Pain 2 5.00 Inflammatory stimuli 1 5.00 Immobilon 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 3 100.00 Osteoarthritis 104 93.40 INFLAMMATION 14 5.00 Arthritis 9 5.00 Disease 5 5.00 Rheumatoid Arthritis 4 5.00 Pain 1 5.00 Apoptosis 1 5.00 Hypertrophy 1 5.00 Frailty 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Next, we investigated the effect of MKK3 or MKK6 knock down on the phosphorylation of p38-MAPK in response to stimulation with IL-1?

Spec (investigated) Regulation (effect) of Gene_expression (knock) of MKK3 associated with targeted disruption

1) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 1.09 Pain Relevance 0.45

General Comments

This test has worked.