INT346520

Context Info Confidence 0.06 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

cytoplasm (TPM3, TFIP11) intracellular (TFIP11) DNA binding (TFIP11) cytosol (TPM3) proteinaceous extracellular matrix (TFIP11) cytoskeleton (TPM3)

Anatomy Link Frequency TM3 1 TPM3 (Homo sapiens) TFIP11 (Homo sapiens)

Pain Link Frequency Relevance Heat Neuropathic pain 4 5.00 Pain 2 5.00 antagonist 2 5.00 agonist 1 5.00 Kinase C 1 5.00 adenocard 1 5.00 Sciatic nerve 1 5.00

Disease Link Frequency Relevance Heat Neuropathic Pain 4 5.00 Pain 2 5.00 Nociception 2 5.00 Stress 2 5.00 Targeted Disruption 1 5.00 Nervous System Injury 1 5.00 Anxiety Disorder 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The model of the PTH2R - TIP39 complex was constructed by placing the ECD model in such a manner that TIP39 could reach into the transmembrane region and interact with the top of TM3 and TM7, a region which has been experimentally verified to discriminate binding of PTHrP to PTH2R [37,38].

TM3 Binding (interact) of TIP39 in TM3

1) Confidence 0.06 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.