INT346527

Context Info Confidence 0.18 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 8 Disease Relevance 0.11 Pain Relevance 0.42

proteinaceous extracellular matrix (TFIP11) nucleus (TFIP11) intracellular (TFIP11) plasma membrane (PTH2R) DNA binding (TFIP11) cytoplasm (TFIP11)

Anatomy Link Frequency parathyroid 2 TM3 1 PTH2R (Homo sapiens) TFIP11 (Homo sapiens)

Pain Link Frequency Relevance Heat Kinase C 8 89.28 antagonist 16 87.04 agonist 8 76.08 adenocard 8 70.96 Neuropathic pain 32 57.60 Pain 16 53.28 Sciatic nerve 8 5.00

Disease Link Frequency Relevance Heat Neuropathic Pain 32 57.60 Pain 16 53.28 Targeted Disruption 8 21.76 Nociception 16 5.00 Stress 16 5.00 Nervous System Injury 8 5.00 Anxiety Disorder 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

TIP39 binds to both receptors, but to PTH2R a hundredfold stronger than to PTH1R and only signal through PTH2R.

PTH2R Binding (binds) of TIP39

1) Confidence 0.18 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0.11

We aim to propose interactions between the parathyroid hormone-2 receptor (PTH2R) and its ligand the tuberoinfundibular peptide of 39 residues (TIP39) by constructing a homology model of their complex.

PTH2R Binding (interactions) of TIP39 in parathyroid

2) Confidence 0.18 Published 2010 Journal BMC Res Notes Section Abstract Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0

In this work, we present a hypothesis of how TIP39 could bind to PTH2R and how the receptor may discriminate among the related peptides TIP39, PTH and PTHrP.

PTH2R Binding (bind) of TIP39

3) Confidence 0.18 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0.11 Pain Relevance 0.15

Positions in PTH2R which have been shown to be directly involved in the discrimination between the PTH and PTHrP for PTH2R; Ile244 (interacts with Leu2 and Ala3 in TIP39 in the model of the complex) in TM3 and Cys397 (matched to Glu12 in TIP39) and Phe400 (in proximity of Ala5 and Ala8 in TIP39) in TM7 are in close contact with the placed ligand [38].

PTH2R Binding (interacts) of TIP39 in TM3

4) Confidence 0.18 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0.04

We aim to propose interactions between the parathyroid hormone-2 receptor (PTH2R) and its ligand the tuberoinfundibular peptide of 39 residues (TIP39) by constructing a homology model of their complex.

parathyroid hormone-2 receptor Binding (interactions) of TIP39 in parathyroid

5) Confidence 0.18 Published 2010 Journal BMC Res Notes Section Abstract Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0

Complexes with the hormones PTH and PTHrP and PTH2R were built by superimposing them upon the TIP39 - PTH2R complex, followed by energy minimisation.

PTH2R Binding (complex) of TIP39

6) Confidence 0.16 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0

Complexes with the hormones PTH and PTHrP and PTH2R were built by superimposing them upon the TIP39 - PTH2R complex, followed by energy minimisation.

PTH2R Binding (complex) of TIP39

7) Confidence 0.16 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0

TIP39 binds to both receptors, but to PTH2R a hundredfold stronger than to PTH1R and only signal through PTH2R.

PTH2R Binding (binds) of TIP39

8) Confidence 0.16 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0.11

General Comments

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