INT347057

Context Info Confidence 0.58 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.05 Pain Relevance 0.14

signal transduction (Gnat2) GTPase activity (Gnat2) signal transducer activity (Gnat2)

Gnat2 (Mus musculus)

Pain Link Frequency Relevance Heat antagonist 18 82.76 Glutamate receptor 6 5.00 addiction 3 5.00 Analgesic 3 5.00 ketamine 3 5.00

Disease Link Frequency Relevance Heat Retina Disease 9 52.88 Targeted Disruption 15 5.00 Sprains And Strains 6 5.00 Camurati-engelmann Disease 6 5.00 Sunburn 6 5.00 Aids-related Complex 3 5.00 Bites And Stings 3 5.00 Ganglion Cysts 3 5.00 Reflex Sympathetic Dystrophy 3 5.00 Mydriatic 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The observation that mice carrying a cytotoxin (DTA) under control of the Gnat2 promoter display aggressive rod degeneration [29]provides indirect support for the concept of Gnat2 expression in rods, as this does not occur with other cone-specific promoters[30].

Gene_expression (expression) of Gnat2

1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993945 Disease Relevance 0 Pain Relevance 0.03

Nevertheless, if Gnat2 really is present in all rods this begs the question of why Calvert et al. (2000) found most Gnat1?

Gene_expression (present) of Gnat2

2) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993945 Disease Relevance 0.05 Pain Relevance 0

Our immunocytochemical evidence for low-level Gnat2 expression in rods provides support for this possibility.

Gene_expression (expression) of Gnat2

3) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993945 Disease Relevance 0 Pain Relevance 0.11

General Comments

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