INT3475

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Context Info
Confidence 0.36
First Reported 1979
Last Reported 1982
Negated 2
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Npc1) nuclear envelope (Npc1) Golgi apparatus (Npc1)
endoplasmic reticulum (Npc1) plasma membrane (Npc1) lysosome (Npc1)
Anatomy Link Frequency
band 2
Npc1 (Mus musculus)
Pain Link Frequency Relevance Heat
opiate 2 99.74 Very High Very High Very High
Morphine 9 99.60 Very High Very High Very High
addiction 2 99.52 Very High Very High Very High
tolerance 2 99.16 Very High Very High Very High
withdrawal 2 98.80 Very High Very High Very High
narcan 3 97.84 Very High Very High Very High
agonist 1 97.12 Very High Very High Very High
Opioid 7 95.56 Very High Very High Very High
Clonidine 1 94.72 High High
adenocard 4 88.56 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine, in vitro, did not alter the phosphorylation of any SPM proteins in the assay, although at a high concentration morphine did antagonize the calcium-stimulated phosphorylation of one or more proteins in band II.
Neg (not) Regulation (alter) of Phosphorylation (phosphorylation) of SPM in band associated with morphine
1) Confidence 0.36 Published 1979 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 759619 Disease Relevance 0 Pain Relevance 0.70
The development of tolerance to and dependence on opiates may include changes in the phosphorylation of specific SPM proteins.
Regulation (changes) of Phosphorylation (phosphorylation) of SPM associated with addiction, tolerance and opiate
2) Confidence 0.16 Published 1979 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 759619 Disease Relevance 0 Pain Relevance 0.68
The injection of saline or an inactive narcotic isomer has no effect on the phosphorylation of striatal SPM proteins.
Neg (no) Regulation (effect) of Phosphorylation (phosphorylation) of SPM
3) Confidence 0.06 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6276532 Disease Relevance 0 Pain Relevance 1.06

General Comments

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