INT347808

Context Info Confidence 0.00 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.47 Pain Relevance 0.12

nucleolus (SMAP2) nucleus (SMAP2) cytoplasm (SMAP2)

SMAP2 (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 1 83.84 Calcium channel 2 79.52 Pain 3 5.00 Potency 2 5.00 palliative 1 5.00 carbamazepine 1 5.00 Analgesic 1 5.00 Neuropathic pain 1 5.00 Pain management 1 5.00 Gabapentin 1 5.00

Disease Link Frequency Relevance Heat Fabry Disease 28 98.96 Lysosome Storage Disease 6 68.72 Gauchers Disease 2 65.60 Pompes Disease 2 63.60 Lipidosis 1 60.88 Gangliosidoses 1 58.72 Disease 7 5.00 Pain 4 5.00 Stroke 3 5.00 Proteinuria 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Chemical chaperones are small molecules that bind to mutant enzyme proteins and assist in their correct folding, maturation, and trafficking to their functional site, such as the lysosome.

small Binding (bind) of

1) Confidence 0.00 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2995157 Disease Relevance 0.47 Pain Relevance 0.12

General Comments

This test has worked.