INT34848

Context Info Confidence 0.70 First Reported 1984 Last Reported 2005 Negated 1 Speculated 0 Reported most in Abstract Documents 11 Total Number 11 Disease Relevance 2.00 Pain Relevance 1.68

Golgi apparatus (B3gat1)

Anatomy Link Frequency livers 2 neuronal 1 HNK-1 1 B3gat1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Paracetamol 8 100.00 cINOD 3 96.96 Morphine 6 95.96 medulla 1 89.08 Potency 1 83.76 Somatostatin 2 83.32 Dopamine 1 74.88 Neuropeptide 2 74.08 Catecholamine 1 71.44 Enkephalin 1 67.28

Disease Link Frequency Relevance Heat Diabetes Mellitus 6 99.44 Experimental Diabetes Mellitus 1 98.08 Ganglion Cysts 7 97.40 INFLAMMATION 3 96.56 Extrahepatic Cholestasis 1 96.44 Ganglioneuroma 1 86.48 Spinal Tumor 2 81.68 Cancer 4 75.00 Gallstones 1 75.00 Pain 1 63.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Full activation of hepatic UDP-glucuronyltransferase occurred when microsomes had been preincubated at 0 C with deoxycholate for 20 min.

Positive_regulation (activation) of hepatic UDP-glucuronyltransferase

1) Confidence 0.70 Published 1984 Journal Life Sci. Section Abstract Doc Link 6429466 Disease Relevance 0 Pain Relevance 0.08

Renal microsomal UDP-glucuronyltransferase activity toward l-naphthol, p-nitrophenol and 4-methylumbelliferone was induced by pretreatment of rats with beta-naphthoflavone and trans-stilbene oxide but not by phenobarbital or 3-methylcholanthrene.

Neg (not) Positive_regulation (induced) of UDP-glucuronyltransferase

2) Confidence 0.61 Published 1984 Journal Life Sci. Section Abstract Doc Link 6429466 Disease Relevance 0 Pain Relevance 0.05

In livers from S4048-treated rats, mRNA levels of genes encoding Glc-6-P hydrolase (approximately 9-fold), Glc-6-P translocase (approximately 4-fold), glycogen synthase (approximately 7-fold) and L-type pyruvate kinase (approximately 4-fold) were increased, whereas glucokinase expression was almost abolished.

Positive_regulation (increased) of Glc-6-P in livers

3) Confidence 0.58 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11346646 Disease Relevance 0 Pain Relevance 0.11

UDP-Glucuronyltransferase activity (UDP-GT) towards acetaminophen resulted increased in 38% (p < 0.05) in the cholestatic group when compared to normal rats.

Positive_regulation (increased) of UDP-Glucuronyltransferase activity associated with paracetamol

4) Confidence 0.47 Published 1993 Journal Acta Gastroenterol. Latinoam. Section Abstract Doc Link 8249530 Disease Relevance 0.17 Pain Relevance 0.33

Renal microsomal UDP-glucuronyltransferase toward l-naphthol was fully activated (six-fold) by 0.03% deoxycholate while the hepatic enzyme was fully activated (eight-fold) by 0.05% deoxycholate.

Positive_regulation (activated) of UDP-glucuronyltransferase

5) Confidence 0.44 Published 1984 Journal Life Sci. Section Abstract Doc Link 6429466 Disease Relevance 0 Pain Relevance 0.09

In livers from S4048-treated rats, mRNA levels of genes encoding Glc-6-P hydrolase (approximately 9-fold), Glc-6-P translocase (approximately 4-fold), glycogen synthase (approximately 7-fold) and L-type pyruvate kinase (approximately 4-fold) were increased, whereas glucokinase expression was almost abolished.

Positive_regulation (increased) of Glc-6-P in livers

6) Confidence 0.42 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11346646 Disease Relevance 0 Pain Relevance 0.11

Inhibition and activation of UDP-glucuronyltransferase in alloxanic-diabetic rats.

Positive_regulation (activation) of UDP-glucuronyltransferase associated with diabetes mellitus

7) Confidence 0.23 Published 1986 Journal Gen. Pharmacol. Section Title Doc Link 3102313 Disease Relevance 0.52 Pain Relevance 0.17

Indomethacin in vitro also caused a loss of cytochrome b5, NADH-cytochrome b5 reductase, NADPH-cytochrome c reductase and epoxide hydrolase activities, but an activation of UDP-glucuronyltransferase.

Positive_regulation (activation) of UDP-glucuronyltransferase

8) Confidence 0.14 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 3778523 Disease Relevance 0.25 Pain Relevance 0.29

Weakly positive immunoreactivity for HNK-1 was also demonstrated in small neuronal cells, consistent with evidence of maturation along a neuronal differentiation.

Positive_regulation (immunoreactivity) of HNK-1 in neuronal

9) Confidence 0.06 Published 1999 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 10587016 Disease Relevance 0.73 Pain Relevance 0.06

Male New Zealand white rabbits were treated with various inducers of hepatic metabolism enzymes to characterize the induction of UDP-glucuronyltransferase (UDP-GT) enzymes.

Positive_regulation (induction) of UDP-glucuronyltransferase

10) Confidence 0.05 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 3091034 Disease Relevance 0 Pain Relevance 0.07

Except for HNK-1, chromogranin-A and B, there was a steady increase in immunoreactive cells for all the remaining antigens up to day 12.

Positive_regulation (increase) of HNK-1 in HNK-1

11) Confidence 0.02 Published 2005 Journal Histol. Histopathol. Section Abstract Doc Link 15736041 Disease Relevance 0.33 Pain Relevance 0.30

General Comments

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