INT349538

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.68
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Smcp, Casp9) cytoplasm (Smcp, Casp9) cytosol (Casp9)
peptidase activity (Casp9) nucleus (Casp9)
Smcp (Mus musculus)
Casp9 (Mus musculus)
Pain Link Frequency Relevance Heat
fortral 4 92.04 High High
agonist 1 91.44 High High
antagonist 1 85.36 High High
cytokine 3 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 48 87.68 High High
Melanoma 63 82.60 Quite High
Cancer 33 66.96 Quite High
Toxicity 5 63.68 Quite High
Malignant Neoplastic Disease 4 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Carcinoma 2 5.00 Very Low Very Low Very Low
Dislocations 1 5.00 Very Low Very Low Very Low
Breast Cancer 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rimcazole did not upregulate TRAIL-R1 or TRAIL-R2 expression (data not shown), but augmented the activation of initiator caspase-8 and initiator caspase-9 upon anti-MCSP:TRAIL treatment (Additional file 3, Figure S2A and B, respectively).
anti-MCSP Neg (not) Positive_regulation (augmented) of Positive_regulation (activation) of caspase-9
1) Confidence 0.04 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.68 Pain Relevance 0.18

General Comments

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