INT349592

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.64
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cyp2c22) nucleus (GTF2H5) DNA binding (GTF2H5)
Anatomy Link Frequency
neuronal 1
GTF2H5 (Homo sapiens)
Cyp2c22 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 166 99.04 Very High Very High Very High
cINOD 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 46 98.20 Very High Very High Very High
Apoptosis 16 96.44 Very High Very High Very High
Injury 1 73.48 Quite High
Acute Renal Failure 1 72.24 Quite High
Stress 2 36.84 Quite Low
Hepatotoxicity 5 28.44 Quite Low
Toxicity 19 5.00 Very Low Very Low Very Low
Overdose 9 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 6 5.00 Very Low Very Low Very Low
Acute Liver Failure 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, TTD, an inhibitor of the 2E1isoform of cytochrome P-450, significantly reduced AAP-induced neuronal death, suggesting a role for this enzymatic activity in the mechanism involved in AAP-mediated neuronal death.
TTD Negative_regulation (inhibitor) of P-450 in neuronal associated with paracetamol and death
1) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.64 Pain Relevance 0.98

General Comments

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