INT349852

Context Info Confidence 0.27 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.30 Pain Relevance 0.15

cell differentiation (Ntrk1) endosome (Ntrk1) aging (Ntrk1) plasma membrane (Ntrk1) cytoplasm (Ntrk1)

Gfra2 (Rattus norvegicus) Ntrk1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat intrathecal 1 88.72 Inflammatory response 6 85.00 Nerve growth factor 1 64.08 Spinal cord 17 57.48 Inflammation 8 5.00 dorsal root ganglion 6 5.00 Neuropeptide 5 5.00 Central nervous system 2 5.00 cerebral cortex 1 5.00 Peripheral nerve injury 1 5.00

Disease Link Frequency Relevance Heat Spinal Cord Injury 29 85.76 INFLAMMATION 14 84.64 Frailty 2 76.24 Injury 35 46.52 Death 12 43.88 Apoptosis 24 30.16 Spinal Injuries 8 5.00 Ganglion Cysts 7 5.00 Contusions 6 5.00 Stress 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We found the simultaneous down-regulation of three out of the four receptors of the GDNF family (Gfra1, Gfra2, Gfra3), as well as the down regulation of Ntrk1 (TrkA) and the Adcyap1r1 receptor.

Gfra2 Negative_regulation (regulation) of Ntrk1

1) Confidence 0.27 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.30 Pain Relevance 0.15

General Comments

This test has worked.