INT350217

Context Info Confidence 0.05 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.09 Pain Relevance 0.09

small molecule metabolic process (HSPG2, ITPR3) nucleoplasm (ITPR3) endoplasmic reticulum (ITPR3) extracellular matrix organization (HSPG2) transmembrane transport (ITPR3) cytoplasm (ITPR3)

HSPG2 (Homo sapiens) ITPR3 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 5 88.88 antagonist 10 82.88 Potency 1 44.44 Glutamate 1 35.44 chemokine 1 34.80 Cannabinoid 8 5.00 imagery 7 5.00 Pain 4 5.00 cytokine 3 5.00 COX2 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 5 88.88 Disease 1 12.00 Pain 4 5.00 Cough 1 5.00 Burns 1 5.00 Pharyngitis 1 5.00 Toothache 1 5.00 Acute Monocytic Leukemia 1 5.00 Snake Bites 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In this metabotropic model, PLC activation would lead to the production of IP3, which in turn would activate the IP3 receptor causing release of Ca2+ from the ER [15].

Positive_regulation (activation) of PLC Positive_regulation (activate) of IP3 receptor

1) Confidence 0.05 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0.09 Pain Relevance 0.09

General Comments

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