INT350433

Context Info Confidence 0.08 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.77 Pain Relevance 0

plasma membrane (KRAS, BRAF) cytosol (BRAF) signal transduction (KRAS) mitochondrion (KRAS) nucleus (BRAF) GTPase activity (KRAS)

Anatomy Link Frequency colon 2 KRAS (Homo sapiens) BRAF (Homo sapiens)

Pain Link Frequency Relevance Heat COX-2 inhibitor 2 5.00 cINOD 2 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Colon Cancer 51 100.00 Apoptosis 6 97.64 Cancer 79 95.64 Metastasis 14 89.16 Breast Cancer 3 74.48 Malignant Neoplastic Disease 4 68.56 Shock 8 50.00 Cervical Cancer 1 18.16 Stress 5 5.00 Carcinoma 5 5.00

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Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Recent publications have shown that the KRAS and BRAF mutation status of colon cancer cells influence the expression rates of multiple proliferative as well as apoptotic signaling intermediates (Kikuchi et al, Cancer Res 2009, Oliveira et al, Oncogene 2003, Seruca et al, 2009), including HIF1?

KRAS Regulation (influence) of Gene_expression (status) of BRAF in colon associated with cancer, colon cancer and apoptosis

1) Confidence 0.08 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.77 Pain Relevance 0

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