INT350503

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.39
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (HSP90AA1, JAK2) cytosol (HSP90AA1, JAK2) signal transduction (HSP90AA1, JAK2)
cell differentiation (JAK2) unfolded protein binding (HSP90AA1) small molecule metabolic process (HSP90AA1)
HSP90AA1 (Homo sapiens)
JAK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloproliferative Disorder 45 93.60 High High
Myelofibrosis 30 93.44 High High
Apoptosis 21 93.16 High High
Splenomegaly 3 89.00 High High
Myelodysplastic Syndromes 38 85.24 High High
Toxicity 1 41.04 Quite Low
Myeloid Leukemia 25 15.28 Low Low
Cancer 9 12.16 Low Low
Chronic Neutrophilic Leukemia 7 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the binding of HSP90 to JAK2 was partially inhibited by LBH589 treatment suggesting that acetylation of HSP90 could be playing a role in the degradation of JAK2 protein.
HSP90 Binding (binding) of JAK2
1) Confidence 0.06 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 1.39 Pain Relevance 0

General Comments

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