INT350520

Context Info Confidence 0.25 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.72 Pain Relevance 0

cell differentiation (SIRT1) nucleoplasm (SIRT1) mitochondrion (SIRT1) nuclear envelope (SIRT1) histone binding (SIRT1) enzyme binding (SIRT1)

SIRT1 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 3 5.00 palliative 1 5.00 chemokine 1 5.00 Nicotine 1 5.00 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 21 99.92 Cancer 9 95.84 Stress 1 84.76 Myeloproliferative Disorder 45 78.00 Myeloid Leukemia 25 71.00 Myelodysplastic Syndromes 38 50.64 Myelofibrosis 30 50.16 Chronic Neutrophilic Leukemia 7 5.00 Disease 6 5.00 Systemic Mastocytosis 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Deacetylation of p53 by HDAC1–3 or SIRT1 inhibits its transcriptional activity, and subsequently, the activation of its downstream molecules, Bax and p21 [93–95].

Phosphorylation (Deacetylation) of SIRT1

1) Confidence 0.25 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.72 Pain Relevance 0

General Comments

This test has worked.